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Frabex

Frabex

IM/IV Injection

🧬 Tranexamic Acid 🏢 Square Pharmaceuticals PLC
Generic Name Tranexamic Acid
Strength 500 mg/5 ml
Manufacturer Square Pharmaceuticals PLC
Unit Price 5 ml ampoule: ৳ 65.00 (3 x 2: ৳ 390.00)

🔹 Indications

🔹 Dosage & Administration

Adults-
  • The usual dose: 500-1000 mg 3 times daily.
  • For prophylaxis: The mean recommended daily doses are 0.5-1 gm orally, 500 mg by the parenteral (intravenous or intramuscular) route.
  • For therapy of hemorrhagic manifestations: the oral dose increases to 1-3 gm given in divided doses: in cases of particular seriousness and urgency, begin by injecting an ampoule (500 mg) slowly by intravenous route and administer the necessary subsequent oral doses.
Children-
  • For prophylaxis: For every kg of body weight from 5-10 mg are orally administered daily in divided doses.
  • For therapeutic purposes: The oral doses are doubled (from 10 to 20 mg/kg), while the intravenous and intramuscular treatment is begun with 10 mg/kg (=0.5 ml every 5 kg) by the slow intravenous route, continuing the oral administration up to the required dose. Where it is more convenient (e.g. in small babies) the ampoules, diluted in a little sweetened water, maybe orally administered instead of the Capsules.
Elderly patients: No reduction in dosage is necessary unless there is evidence of renal failure.

🔹 Interaction

Frabex is a synthetic Amino Acid that is incompatible with solutions containing penicillins (eg: Benzyl penicillin). Thrombolytic drugs like Streptokinase & Urokinase antagonise the antifibrinolytic action of Frabex. The potential for thrombus formation may be increased by concomitant administration of estrogen containing drugs, like oral contraceptives. Direct admixture of Frabex with whole blood should be avoided during Transfusion.

🔹 Contraindications

Known individual hypersensitivity to the product. Thromboembolic disease, arterial and venous thrombosis, endocavitary hemorrhages, serious kidney failure.

🔹 Side Effects

  • Frabex is generally well tolerated; there may be infrequent cases of sense of fatigue, conjunctival irritation, nasal blockage, itching, skin reddening, exanthems.
  • After oral administration there may be sign of nausea, diarrhea, gastric pyrosis.
  • There are rare cases of postural hypotension.
  • In the case of hypersensitivity to Frabex, avoid or suspend treatment and start a suitable therapy.

🔹 Pregnancy & Lactation

Since the transplacental passage of the drug and its possible effects on the fetus are unknown, Tranexamic Acid should not be administered during known and presumed pregnancy. Tranexamic Acid passes into breast milk to a concentration of approximately one hundredth of the concentration in the maternal blood. An antifibrinolytic effect in the infant is unlikely.

🔹 Precautions & Warnings

  • Frabex should be used in cases where there is hyperfibrinolysis. The prophylactic treatment must begin 24 hours before the operation and continue until 3-4 days after it.
  • The therapy of hemorrhages must be prolonged for at least 24 hours after manifestations have disappeared.
  • In hematuria, especially when this is not accompanied by any other hemorrhagic manifestations, reduce the doses to prevent formation of clots in the urinary tract.
  • Frabex must not be used in serious renal insufficiency or anuric syndromes and must only be used with caution in less serious renal dysfunctions.
  • The administration of product requires particular care in cardiopathic and hepatopathic subjects.

🔹 Storage Conditions

Store in a dry place at 15-30°C, away from light and keep out of children's reach.

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💡 Frequently Asked Questions

In medicine: Prophylaxis and therapy of hemophtoes, digestive hemorrhages, hemorrhagic syndromes in leukaemia, cirrhosis and hemophilia, thrombocytopenic purpura, accidents during thrombolytic therapy and transfusion.In surgery: Prophylaxis and antih...
Adults- The usual dose: 500-1000 mg 3 times daily. For prophylaxis: The mean recommended daily doses are 0.5-1 gm orally, 500 mg by the parenteral (intravenous or intramuscular) route. For therapy of hemorrhagic manifestations: the oral dose inc...
Frabex is generally well tolerated; there may be infrequent cases of sense of fatigue, conjunctival irritation, nasal blockage, itching, skin reddening, exanthems. After oral administration there may be sign of nausea, diarrhea, gastric pyrosis....

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